Squeak and rattle (S&R) problems in body structure and trim parts have become serious issues for automakers because of their influence on the initial quality perception of consumers. In this study, various CAE and experimental methods developed by Hyundai Motors for squeak and rattle analysis of door systems are reported. Friction-induced vibration and noise generation mechanisms of a door system are studied by an intelligent combination of experimental and numerical methods. It is shown that the effect of degradation of plastics used in door trims can be estimated by a numerical model using the properties obtained experimentally. Effects of changes in material properties such as Young's modulus and loss factor due to the material degradation as well as statistical variations are predicted for several door system configurations. As a new concept, the rattle and squeak index is proposed, which can be used to guide the design. The predicted S&R of the door system from the CAE process were compared with experimental results. Practical applications of the developed process and possible future directions of CAE based S&R analysis are discussed.