Artificial intelligence systems are highly accepted as a technology to offer an alternative way to tackle complex and non-linear problems. They can learn from data, and they are able to handle noisy and incomplete data. Once trained, they can perform prediction and generalization at high speed. The aim of the present study is to propose a novel approach utilizing the adaptive neuro-fuzzy inference system (ANFIS) and the fuzzy clustering method for automotive ride performance estimation. This study investigated the relationship between the automotive ride performance and relative parameters including speed, spring stiffness, damper coefficients, ratios of sprung and unsprung mass. A Takagi-Sugeno fuzzy inference system associated with artificial neuro network was employed. The C-mean fuzzy clustering method was used for grouping the data and identifying membership functions. The prediction results were compared with simulation testing data and experimental data of a typical A-Class automobile.