This study presents an efficient process to optimize the transmission loss of a vehicle muffler by using both experimental and analytical methods. Two production mufflers were selected for this study. Both mufflers have complex partitions and one of them was filled with absorbent fiberglass. CAD files of the mufflers were established for developing FEA models in ANSYS and another commercial software program (CFEA). FEA models were validated by experimental measurements using a two-source method. After the models were verified, sensitivity studies of design parameters were performed to optimize the transmission loss (TL) of both mufflers. The sensitivity study includes the perforated hole variations, partition variations and absorbent material insertion. The experimental and sensitivity analysis results are included in the paper.