Aero-vibro-acoustic prediction of interior noise associated with exterior flow requires accurate predictions of both fluctuating surface pressures across the exterior of a vehicle and efficient models of the vibro-acoustic transmission of these surface pressures to the interior of a vehicle. The simulation strategy used in this paper combines both CFD and vibro-acoustic methods. An accurate excitation field (which accounts for both hydrodynamic and acoustic pressure fluctuations) is calculated with a hybrid CAA approach based on an incompressible unsteady flow field with an additional acoustic wave equation. To obtain the interior noise level at the driver's ears a vibro-acoustic model is used to calculate the response of the structure and interior cavities. The aero-vibro-acoustic simulation strategy is demonstrated for a Mercedes-Benz S-class and the predictions are compared to experimental wind tunnel measurements.