This paper presents an innovative approach for modular and flexible positioning systems for large aircraft assembly, for instance the manufacturing of the fuselage sections from shell panels and floor grids, the alignment of the sections to build the fuselage, and the joining of wings and tail units to the fuselage. The positioning system features a modular, reconfigurable, and versatile solution for various aircraft dimensions and different applications. This includes the positioning units, the controls, the measurement interface and the product supports. It provides the customer with a holistic solution that considers the specific positioning task taking into account high absolute positioning accuracy, repeatability and synchronization of the motion for all manipulators that constitute the positioning system. Various tools and method which were used during the development process are introduced and the developed standardized Positioning Technology is briefly explained.