Heavy vehicles have the characteristics of with high center of gravity position, large weight and volume, wheelbase is too narrow relative to the body height and so on, so that they always prone to rollover. In response to the above heavy security problems of heavy vehicle in running process, this paper mainly analyzes roll stability and yaw stability mechanism of heavy vehicles and studies the influence of vehicle parameters on stability by establishing the vehicle dynamics model. At the same time, this paper focuses on heavy vehicles stability control methods based on simulation and differential braking technology. At last, verify the effect of heavy vehicle stability control by computer simulation. The results shows that self-developed stability control algorithm can control vehicle stability effectively, so that the heavy vehicles instability can be avoided, the vehicle driving safety and braking stability are improved.