This paper examines truck driver injury and loss of life in truck crashes related to cab crashworthiness. The paper provides analysis of truck driver fatality and injury in crashes to provide a better understanding of how injury occurs and industry initiatives focused on reducing the number of truck occupant fatalities and the severity of injuries. The commercial vehicle focus is on truck-tractors and single unit trucks in the Class 7 and 8 weight range. The analysis used UMTRI's Trucks Involved in Fatal Accidents (TIFA) survey file and NHTSA's General Estimates System (GES) file for categorical analysis and the Large Truck Crash Causation Study (LTCCS) for a supplemental clinical review of cab performance in frontal and rollover crash types.The paper includes analysis of crashes producing truck driver fatalities or injuries, a review of regulatory development and industry safety initiatives including barriers to implementation. A set of countermeasures to address truck driver safety risk are presented.