The continuously strengthened requirements regarding air quality and pollutant reduction as well as GHG emissions further complicate the compliance with legal standards. Especially in view of cost-sensitive applications this demand strongly collides with the EMS set-up and the sensor requirements with still increasing overall system complexity.The paper in hand describes a novel air path control approach, which offers the potential for a flexible use of multiple EGR routes to meet upcoming legislations more robustly, while providing a significant reduction of calibration effort and sensor content at the same time. By using a direct emission based cylinder charge control, also alterations in operational ambient conditions are covered with system reactions according to physical-based rules to enhance the engine-out emission performance without need for tuning of corrections of any air path set point. This enables a system to fulfil EU-4 and EU-5 emission requirements in very cost attractive way, but also to meet EU6.2 and RDE legislation requirements with slightly increased sensor set-up, while using the same software strategies. In addition to the functional correlations and principle layout of the novel algorithms, the paper delivers also validated experimental results for a clear proof-of-concept and identifies the merits in engineering and calibration effort.