The purpose of this paper is present a successfully application of Design For Assembly (DFA) and Design for Manufacturing (DFM) on Pickup-Box reinforcement. Those powerful quality tools are widely used during automotive design development and it might be a competitive design solution. As an introduction, a complete DFA and DFM revision is provided in order to allow methodology comprehension. Currently automakers technologies are shown as well. An introduction about product development process is presented in order to contextualize the DFA/DFM application in a real design situation. A rich and detailed revision about Pickup versions and body structure concept are covered as well. The study of case about DFA/DFM application on Mid-size Pickup-box Inner asm reinforcement generated 36-42% of mass reduction and 58-66% of cost reduction.