Brake-by-wire (BBW) system has drawn a great attention in recent years as driven by rapidly increasing demands on both active brake controls for intelligent vehicles and regenerative braking controls for electric vehicles. However, unlike conversional brake systems, the reliability of the brake-by-wire systems remains to be challenging due to its lack of physical connection in case of system failure. There are various causes for the failure of a BBW system, such as failure of brake controller, loss of sensor signals, failure of communication or even power supply, to name a few. This paper presents a fault-tolerant control under novel control architecture. The proposed control architecture includes a driver command interpreter module, a command integration module, a control allocation module, a fault diagnosis module and state observers. The fault-tolerant control is designed based on a quadratic optimal control method with consideration of actuator constraints. Then a simulation platform has been established and extensive simulations have been conducted. The results have demonstrated the validity and effectiveness of the proposed control architecture and method.