The power demand of air conditioning in PHEVs is known to have a significant impact on the vehicle’s fuel economy and performance. Besides the cooling power associated to the passenger cabin, in many PHEVs, the air conditioning system provides power to cool the high voltage battery. Calculating the cooling power demands of the cabin and battery and their impact on the vehicle performance can help with developing optimum system design and energy management strategies. In this paper, a representative vehicle model is used to calculate these cooling requirements over a 24-hour duty cycle. A number of pre-cooling and after-run cooling strategies are studied and effect of each strategy on the performance of the vehicle including, energy efficiency, battery degradation and passenger thermal comfort are calculated. Results show that after-run cooling of the battery should be considered as it can lead to significant reductions in battery degradation. Results also show that despite the impact on energy consumption, pre-cooling the cabin and battery in extreme climate conditions is inevitable to achieve the required comfort levels.