The objective of this paper is to demonstrate that frequency domain methods for calculating structural response and fatigue damage can be more widely applicable than previously thought. This will be demonstrated by comparing results of time domain vs. frequency domain approaches for a series of fatigue/durability problems with increasing complexity. These problems involve both static and dynamic behavior. Also, both single input and multiple correlated inputs are considered. And most important of all, a variety of non-stationary loading types have been used. All of the example problems investigated are typically found in the automotive industry, with measured loads from the field or from the proving ground.