A low frequency vibration issue around 3.2 Hz occurs during a commercial heavy truck program development process, and it is linked to extremely uncomfortable driving and riding experiences. This work focuses on an analytical effort to resolve the issue by first building a full vehicle MBS (multi-body-system) model, and then carrying out vibration response analyses. The model validation is performed by using full vehicle testing in terms of structural modes and frequency response characteristics. In order to resolve the issue which is excited by tire non-uniformity, the influence of the cab suspension, frame modes, front leaf spring system and rear tandem suspension is analyzed. The root cause of the issue is found to be the poor isolation of the rear tandem suspension system. The analytical optimization effort establishes the resolution measure for the issue.