The mathematical models that predict friction losses for an internal combustion (IC) engine are described in this paper. These models are based on a combination of fundamental physics and empirical results. These include predictions of losses arising from friction and viscous fluid motion associated with the relative movement of solid surfaces within a piston assembly, the cranktrain, and valvetrain components. The engine friction losses are defined in the context of the geometries of the particular components within an IC engine. Details of these formulations are given, including novel geometry-related coefficients. Different regimes of lubricated friction are considered. In order to establish the model fidelity and robust solution methodology, the mathematical models are validated against engine friction tests. Utilization of these models enables practical solutions to the development of new low friction IC engines that leads to improved engine mechanical efficiency and fuel economy.