As a potential material for lightweight vehicle, polymethyl methacrylate (PMMA) has proven to perform well in optical behavior and weather resistance. However, the application in automotive glazing has seldom been studied. This paper investigates the defrost performance of PMMA rear window using both numerical and experimental methods. The finite element analysis (FEA) results were found to be in good agreement with the experimental data. Based on the validated finite element model, we further optimized the defrost efficiency by changing the arrangement of heating lines. The results demonstrated the frost layer on the vision-related region of PMMA rear window can melt within 30 minutes, which meets the requirement of defrost efficiency.