The 48V mild hybrid technology is emerging as a very attractive option for high-volume vehicle electrification. Compared to high-voltage hybrids, the 48V system has a potential of achieving competitive fuel economy with significantly lower incremental costs. While previous studies of 48V mild hybrid systems discussed vehicle configuration, power management strategy and electric machine design, quantitative assessment of fuel economy under real-world conditions remains an open topic. Objectives of this paper are to propose a methodology for categorizing real-world cycles based on driver aggressiveness, and to subsequently analyze the impact of driving patterns on fuel saving potentials with a 48V mild hybrid system. Instead of using the certification test cycles to evaluate the fuel economy, real-world cycles are extracted from 2001-2003 Southern California Household Travel Survey. Subsequently, a consistent energy management strategy is implemented into the vehicle simulation and the real-world fuel consumption reductions are quantified for different levels of driver aggressiveness.