As one of many pack-level battery simulation approaches developed within the General Motors-led Computer-Aided Engineering of Automotive Batteries (CAEBAT) Phase 1 project, the system approach treats the entire battery pack as a dynamic system which includes multiple engineering disciplines for simulation. It is the most efficient approach of all the CAEBAT battery pack-level approaches in terms of computational time and resources. This paper reports the application of the system approach for a 24-cell liquid-cooled prototype battery pack. It also summarizes the verification of the approach by comparing the simulation results with the measurement data. The results using the system approach are found to have a very good agreement with the measurements.