The ignition delay times of 2, 5-Dihydrofuran (25DHF) were measured behind reflected shock waves at the pressures of 4, 10atm, temperatures of 1110-1650 K, for the lean (φ= 0.5) and stoichiometric (φ= 1.0) mixtures with fixed fuel concentration of 0.5%. The correlations of ignition delay times to initial parameters were fitted in an Arrhenius-like form for the two fuels by multiregression analysis. Simulations based on Liu model, Somers model and Tran model were presented and compared to experiment data. Subsequently, reaction pathway and sensitivity analysis were performed in low and high temperature to obtain insight into the ignition kinetic by using Liu model. Reaction path analysis shows that there are two main ways in the consumption of 25DHF and the main intermediates are C3H5Y, sC3H5 and propylene etc. Some reactions which involved the main intermediate products presented important effect on the whole ignition of 25DHF. The comparisons to furan and MTHF on ignition delay time data were also conducted. The ignition delay times of 25DHF were shorter than that of furan and the slopes of ignition delay times of 25DHF were smaller than that of furan and MTHF, proving lower activation energy.