Toyota Safety Sense is a safety system package developed to help drivers avoid accident types with a high frequency of occurrence. This paper deals with pre-collision system which forms the core of Toyota Safety Sense, especially Toyota Safety Sense P which uses a combined sensor configuration consisting of a monocular camera paired with millimeter wave radar, in order to achieve both high recognition performance and reliability. The use of a wide-angle monocular camera, millimeter wave radar integrated in the front grill emblem, and a collision determination algorithm for pedestrian targets enabled the development of a pre-collision system comprising detection capability of crossing pedestrians. Toyota has developed warning and pre-collision brake assist for driver to assist in avoiding a collision effectively; In addition, Pre-collision brake has achieved high level of performance for the drivers who cannot avoid a collision. Conformance checking with field driving data from various locations worldwide has proved in high safety performance compliant with global preventive safety assessment principles.