To analyze the K&C (kinematics and compliance), handling and stability performance of the vehicle chassis, some simulations are usually performed using a multi-body dynamics software named ADAMS. This software introduces assumptions that simplify the components of the suspension as rigid bodies. However, these assumptions weaken the accuracy of the simulation of ADAMS. Therefore the use of flexible bodies in K&C and handling and stability simulation in ADAMS is needed to conduct more precise suspension system designs.This paper mainly analyses the influences of the subframe flexibility on handling and stability simulation in ADAMS/Car. Two complete vehicle models are built using ADAMS/Car and Hypermesh. The only difference between the two models is the subframe of the front McPherson suspension. One of the subframes is simplified as a rigid body. The other one is a flexible body built using the MNF file from Hypermesh.After that, the full-vehicle simulations for the two different models are performed in some operation conditions according to the passenger car test standards. With the characteristic values from the simulation results, the handling and stability performances of the two vehicles can be evaluated using evaluation standards. By comparing the characteristic values and evaluation scores of the two models, differences are observed. This implies that the flexibility of the subframe in a front McPherson suspension will influence the handling and stability performance of the vehicle when simulating in ADAMS/Car.