This paper describes the prediction process of wheel forces and moments via indirect transfer path analysis, followed by an analysis of the influence of wheel variants and suspension modifications. It proposes a method to calculate transmission of noise to the vehicle interior where wheel forces and especially moments were taken into account. The calculation is based on an indirect transfer path analysis with geometrical modifications of the frequency response functions. To generate high quality broadband results, this paper also points out some of the main clearance cutting criteria.The method has been successfully implemented to show the influence of wheel tire combinations as well as the influence of suspension modifications. Case studies have been performed and will be presented in this paper. Operational noise and vibration measurements have been carried out on Daimler NVH test tracks. The frequency response functions were estimated in an acoustic laboratory. The combined analysis showed a good correlation between noise measurements and the prediction results. It was also possible to point out the importance of road induced moments for the transmission behavior.