Due to more stringent emission regulation, especially plug-in hybrid vehicles have an increased attractiveness for OEMs to reduce OEM’s CO2 fleet emission. Generally, hybrid vehicles have a much higher complexity than conventional vehicles. This gives an additional degree of freedom for the development but also increases the number of potential NVH topics dramatically. Therefore, the role of frontloading and early prototype testing is getting even higher importance than in standard developments.Current hybrid vehicles on the market are mainly ICE vehicles with electric boosting or starting functionality only. This however will not be sufficient to fulfill the OEM’s CO2 fleet emission requirements. Future hybrid vehicles will have much higher electrical capabilities and drive much more in pure electric modes. Therefore, the more frequent change between the different driving modes and the related mode transitions will lead to a more complex interior NVH situation. In this paper, major NVH challenges with such advanced hybrid vehicles will be discussed.