With the development of automotive HMI and mobile internet, many interactive modes are available for drivers to fulfill the in-vehicle secondary tasks, e.g. dialing, volume adjustment, music playing. For driving safety and drivers’ high expectation for HMI, it is urgent to effectively evaluate interactive mode with good efficiency, safety and good user experience for each secondary tasks, e.g. steering wheel buttons, voice control. This study uses a static driving simulation cockpit to provide driving environment, and sets up a high-fidelity driving cockpit based on OKTAL SacnerStudio and three-dimensional modeling technology. The secondary tasks supported by HMI platform are designed by customer demands research. The secondary task test is carried out based on usability test theory, and the influence on driving safety by different interactive modes is analyzed. By F-ANP fuzzy network analysis method, the different influence factors of secondary task interactive modes are taken into consideration comprehensively, and an evaluation model is set up, while safety and usability are the first level index. Then a comprehensive evaluation is carried out on different secondary tasks, and the model is verified according to customer satisfaction degree. Finally, the evaluation result is tentatively integrated with the user population characteristics to do the correlation analysis. It is found that the score of in-vehicle secondary task interaction experience by the same interaction method has certain relationship with user gender and age. This paper offers reference for the design, application and evaluation of different new HMI technologies in the car.