In respect to the present large refrigerator trucks, a sub-engine type is main product, but the basic structure does not greatly change since the introduction for around 50 years. A sub-engine driving a compressor uses an engine for the industrial instrument, and the environmental correspondence such as the fuel consumption, the emission is late remarkably. In addition, most of trucks carry the truck equipment including the refrigerator which consumes the fuel about 20% of whole vehicle. Focusing on this point, the follows are the report about the manufacture of the system planning the fuel consumption reduction of the large size refrigerator truck by a new concept to use HV power supply for the electric-driven refrigerator. We have developed a fully electric-driven refrigerator system, which uses regenerated energy that is, dedicated for the refrigerator system. It is the world's first new concept to use the all electricity that regenerated by HV system for the drive of the electric refrigerator, not for a run assist. It ensures the high quality and stable refrigerator performance and realizes the reduction of the fuel for the freezing and the low noise. Furthermore, in addition to light-weighting by the sub-engine non-deployment, the maintenance expense can decrease because of the simple drive and the piping. By the all-in-one unit structure which is integrated an electric compressor with evaporator and a condenser, the refrigerant piping is largely shortened and the efficiency and the reliability of the refrigerator is improved. We have proven that the system is able to save fuel consumption, caused by the refrigerator, by 64% by applying new control system which considers cooperation with the vehicle hybrid control system.