In respect to the present large refrigerator trucks, sub-engine type is the main product, but the basic structure does not change greatly since the introduction for around 50 years. A sub-engine type uses an industrial engine to drive the compressor, and the environmental correspondence such as the fuel consumption, the emission is late remarkably. In addition, most of trucks carry the truck equipment including the refrigerator which consumes fuel about 20% of whole vehicle. Focusing on this point, the following are the reports about the system development plan for fuel consumption reduction of the large size refrigerator truck. New concept is to utilize electrical power from HV system to power the electric-driven refrigerator. We have developed a fully electric-driven refrigerator system, which uses regenerated energy that is dedicated for our refrigerator system. It is the world’s first new concept to use the all electricity that regenerated by HV system for the drive of our electric refrigerator, not only for a run assist. Not limited to the high quality and stability refrigerator performance, it also realizes the reduction of the fuel and noise during the freezing operation. Fuel consumption reduced due to light weight drive system by replacing the heavy sub-engine to an electric compressor and also elimination of additional fuel line for sub-engine. Also, the maintenance expense can decrease because of the simple drive system and piping layout. By the all-in-one unit structure which is integrated an electric compressor close to the evaporator and condenser, the refrigerant piping is largely shortened and the efficiency and the reliability of the refrigerator are improved. We have proven that the system is able to save fuel consumption up to 64% by applying new control system which considers cooperation with the vehicle hybrid control system.