Adopting parametric approach to optimize CAE models for various objectives is a common practice these days. Connection entities such as welds and adhesive play a very important role in overall performance matrix and hence adding them to the pool of design variables during an optimization exercise provides additional design space. This paper evaluates the possibility to use structural adhesives as patches rather than continuous lines. The method presented in this paper offers unique approach to parameterize adhesive lines. The paper discusses an optimization study with structural adhesives patches along with spot weld pitch as design variables. Body in White (BiW) and Trimmed Body in White (TBiW) models are used for analysis .The goal of the study is to reduce total length of structural adhesive as well as number of welds while maintaining baseline NVH performance as constraints.