Because of the importance of lightweight constructions and the reduction of production time and costs, nowadays other materials more and more substitute components, which are made of metals so far. The usage of continuously carbon fiber reinforced laminates instead of metals seems self-evident in many cases because of their high specific strength and the low specific weight. The available material-data of this material group from datasheets are mostly static values like tensile strength and fracture elongation. For the dimensioning of parts having regard to geometry, loading conditions and material behavior, static material data are not sufficient. For the dimensioning of dynamically loaded components concerning the fatigue life, the knowledge of the local S/N-curve is necessary. These local S/N-curves, determined by the material, are essentially influenced by component specific effects, such as fiber orientation, type of loading, mean stress, temperature, production process and many more. For fatigue life prediction an assessment method was established, which takes into account the fiber orientation and considers different types of failure mechanisms like fiber fracture, inter fiber fracture and delamination. As input data, structural stresses are needed analyzed by the Finite Element Method, where the local orthotropic material behavior for each ply has been considered. Nevertheless, the fatigue behavior of continuous fiber reinforced plastics is rather complex and a lot of tests on specimens are necessary to quantify influences as fiber orientation, mean stress influence, and others. A hypothesis for fatigue life prediction of orthotropic carbon fiber reinforced materials has been derived based on the well-known static failure criterion of Puck, implemented into a standard fatigue software tool and verified so far with component tests. The hypothesis is applicable even for general random-like and multi-axial loads.