Fatigue crack growth tests have been carried out to investigate the mixed mode fatigue crack propagation behavior of an automotive structural adhesive BM4601. The tests were conducted a compound CMM (Compact Mixed Mode) specimen under load control with 0.1 R ratio and 3Hz frequency. A long distance moving microscope was employed during testing to monitor and record the real time length of the fatigue crack in the adhesive layer. The strain energy release rates of the crack under different loading angles, crack lengths and loads were calculated by finite element method. The pure mode I and mode II tests show that an equal value of mode I strain energy release rate results in over ten times higher FCGR (Fatigue Crack Growth Rate) than the mode II stain energy release rate does. The mixed mode tests results show that under a certain loading angle, the mixed mode FCGR is changed by changing the load, which is contrary to the find in pure mode I and mode II tests.