Ensuring durability is one of the key requirements while developing cooling modules for various powertrains. Typically, road surface induced loads are the main driving force behind mechanical failures. While developing the components, road load accelerations are utilized in CAE simulations to predict the high-stress regions and estimate the fatigue life of the components mounted on the body. In certain scenarios where components are mounted to the body and attached to the engine with hoses, the components can experience additional loads associated with engine vibration. This attachment scheme requires a different analysis methodology to determine fatigue life.In the proposed paper, we look at the effect of engine motion (EM) on the fatigue life of internal transmission oil cooler (ITOC) which is mounted on the body through radiator and is simultaneously connected to the engine using a steel pipe. We propose a new CAE methodology taking into account the engine motion displacements.