Ensuring durability is one of the key requirements while developing cooling modules for vehicles. Cooling modules typically include radiator, charge air cooler, transmission oil cooler, low-temp radiator and condenser. Typical loading on cooling modules comes from body, in the form of road loads. The road load accelerations are commonly utilized to predict the high-stress regions and predict the fatigue life of the components. In certain cases where components are attached to both body and engine, the cooling module components can experience additional loads which might require additional analysis to determine the fatigue life. In the proposed paper we look at the effect of engine roll on the fatigue life of transmission oil cooler which is mounted on the body through radiator and is simultaneously connected to the engine using a steel pipe. Bench tests were used to prove out the mode of failure observed in the simulations.