In an automobile, road loads due to tire-road interaction are transferred to vehicle body through suspension. This makes suspension a critical component from the body durability perspective. During vehicle design and development, optimization of suspension parameters to suit ride and handling performance is a continuous and iterative process. These changes on suspension can affect vehicle body durability performance. This paper tries to establish a process to evaluate the effect of changes in suspension parameters on body durability, thus helping in understanding the impact of these changes.The process starts with virtual model building in Multi Body Dynamics software. The base line model is correlated with testing using fatigue at some critical locations on Body in White (BIW). Once correlated, Design of Experiments (DOE) approach is used on suspension parameters like spring properties, damper properties etcetera to identify critical parameters that will affect the magnitude of loads on the body-suspension attachment points. These loads are further used to evaluate effect on durability of the body using Finite Element Method (FEM) approach.