The performance of modern boosted gasoline engines is limited at high loads by knock, stochastic Low Speed Pre-Ignition as well as Megaknock. The main objective of the present work is to develop a predictive combustion model to investigate auto-ignition and megaknock events at high load conditions in gasoline engines. A quasi one-dimensional combustion simulation tool has been developed to model abnormal combustion events in gasoline engines using detailed chemical kinetics and a multi zone wall heat transfer model. The model features six boundary layers representing specific geometrical features such as liner and piston with individual wall temperatures and chemistry to accurately track the individual zone’s thermodynamic properties. The accuracy of the utilized auto-ignition and one-dimensional spark ignition combustion models was demonstrated by validating against experimental data. The multi-zone combustion model accurately simulates hot spot induced auto-ignition as well as conventional combustion.