Nowadays, detailed kinetics is necessary for a proper estimation of both flame structure and pollutant formation in compression ignition engines. However, large mechanisms and the need to include turbulence/chemistry interaction introduce significant computational overheads. For this reason, tabulated kinetics is employed as an possible solution to reduce the CPU time despite table discretization is generally limited by memory occupation. In this work, to keep an acceptable table size and incorporate turbulence/chemistry interaction, authors applied tabulated perfectly stirred reactors (PSR) to compute reaction rates in three combustion models characterized by different flame structure assumptions: well-mixed, representative interactive flamelets and Eulerian-Field transported PDF. The proposed approach represents a good compromise between accuracy, required memory and computational time. The experimental validation was carried out by considering both constant-volume vessel and Diesel engine experiments. First, the ECN Spray A configuration was simulated at different operating conditions and results from the three different flame structures are compared with experimental data of ignition delay, flame lift-off, radicals and soot distributions. Afterwards, engine simulations were carried out and computed data are validated by cylinder pressure and heat release rate profiles.