CFD modeling of practical engines have been limited in terms of predictability due to stiff chemical kinetics, small length and time scales and turbulence chemistry interaction. Tabulation of chemistry has shown promising results in speeding up high fidelity CFD simulations of standardized experiments. In this work a novel flamelet tabulation technique (TFM: tabulated flamelet model) is extended to model combustion in an optical engine with methyl decanoate (MD) as fuel. Previous experimental investigations have suggested significantly lower soot formation while using MD as a fuel. These experimental results have been used to validate the flamelet model for a range of engine operating conditions. The results are also compared to the homogeneous reactor (well-mixed) model and the multi-flamelet RIF model. Quantitative and qualitative differences in flame development have been presented for the different modeling approaches. The data from the optical engine shows that the tabulated flamelet approach is able to predict the flame liftoff lengths, heat release rate and in-cylinder pressures accurately. These validations are carried out for a range of EGR and injection pressure conditions. Two different MD chemistry mechanisms with 115 species and 239 species have been evaluated. Grid resolution studies were carried out using three different grid sizes to demonstrate grid convergence. The results show the efficacy of a tabulated model to include turbulence chemistry interaction and large chemistry mechanisms for engine simulations at substantially lower computational costs.