Mechanical load and thermal load are the two main barriers limiting the engine power output of heavy duty (HD) diesel engines. Usually, the peak cylinder pressure could be reduced by retarding combustion phasing while introducing the drawback of higher thermal load and exhaust temperature. In this paper, Miller cycle with late intake valve closing was investigated at high speed high load condition (77 kW/L) on a single cylinder HD diesel engine. The results showed the simultaneous reduction of mechanical and thermal loads. In the meanwhile, higher boosting pressure was required to compensate the Miller loss of the intake charge during intake and compression process. The combustion temperature, cylinder pressure, exhaust temperature and NOx emission were reduced significantly with Miller cycle at the operating condition. Furthermore, the combustion process, smoke number and fuel consumption were analysed.