The compatibility of notable infrastructure elastomers with bio-blendstock derived single molecule fuel candidates and their blends with a gasoline representative were examined using solubility analysis. The elastomer materials include fluorocarbon, acrylonitrile butadiene rubber (NBR), styrene butadiene (SBR), neoprene, polyurethane and silicone. These materials have been rigorously studied with other fuel types, and their volume change results were found to correspond well with their predicted solubility levels. The fuel candidates include alcohols, alkanes, alkenes, aromatics, esters, ethers and ketones. Dodecane was used as a baseline gasoline (or E0) representative along with a blend of dodecane and 10% ethanol (E10). A Hansen solubility analysis was performed for each elastomer with each fuel candidate and a blend of each fuel candidate with dodecane. The results indicate that the majority of the alcohols, alkanes, alkenes and aromatics will be compatible with existing infrastructure elasotmers. For the ester fuel candidates, the results are mixed and fluorocarbon and neoprene may exhibit higher solubility for some ester types. Neoprene and polyurethane show increased solubility (or reduced compatibility) with many of the ether candidates, while fluorocarbon and neoprene show poor compatibilities with ketones. When blended with dodecane (as a gasoline representative) the solubilities for many of these materials with the candidate fuels were observed to increase for fuel candidate concentrations between 20 and 50%.