Combustion systems with advanced injection strategies have been studied extensively, but there exists a significant fundamental knowledge gap on fuel spray interactions with the piston surface and chamber walls. This paper aims to present the results of experimental studies and numerical simulations of high pressure fuel spray impinging on the wall. The experimental work of spray-wall impingement, including non-vaporizing and vaporizing spray characterization, was carried out in a constant-volume high pressure-temperature pre-burn type combustion vessel (CV). The simultaneous Mie scattering of liquid spray and Schlieren of liquid and vapor spray were used. Diesel fuel was injected at a pressure of 1500 bar with ambient charge gases at a density of 22.8 kg/m3 with isothermal (ambient and plate temperatures of 423 K) and non-isothermal (ambient temperature of 900 K and plate temperature of 423 K) conditions. An Eulerian-Lagrangian modeling approach was employed to characterize the spray-gas and spray-wall interactions in the Converge framework by means of a Reynolds-Averaged Navier-Stokes (RANS) formulation. A set of turbulence and spray break-up model constants was identified to properly match the aforementioned measurements of liquid and vapor penetration within their experimental confidence intervals. An accuracy study on varying the minimum mesh size was also performed to ensure the grid convergence of the numerical results. Experimentally validated CFD simulations were then used to investigate the local spray characteristics in the vicinity of the wall with a particular attention on Sauter Mean Diameter (SMD) and Reynolds and Weber number. The analysis was performed by considering before- and after-impingement conditions with the aim of taking in account the influence of the impinged wall on the spray morphology.