Recently, the European Union has adopted a new regulation on Real-Driving-Emissions (RDE) and also China is considering RDE implementation into new China 6 legislation. The new RDE regulation is focused on measuring nitrogen oxides (NOx) and particulate number (PN) emissions of both light-duty gasoline and diesel vehicles under real world conditions. A supplemental RDE test procedure was developed for European type approval, which includes on-road testing with cars equipped with portable emission measurement systems (PEMS). This new regulation will significantly affect the engine calibrations and the exhaust gas aftertreatment. In this study the impact of the new RDE regulation on two recent EU 6b certified turbocharged direct injected gasoline vehicles has been investigated. A comparison of several chassis dyno drive cycles with two new defined on-road RDE cycles was performed. Moreover, different exhaust aftertreatment systems including state of the art three-way catalyst (TWC) and catalyzed gasoline particulate filter (cGPF) technologies were investigated under real world conditions. The results demonstrate that combined systems of TWC plus cGPF are robust aftertreatment solutions for both NOx and PN emissions under RDE requirements.