Manufacturers have been encouraged to accommodate advanced downsizing technologies such as the Variable Displacement Engine (VDE) to satisfy commercial demands of comfort and stringent fuel economy. Particularly, Active control engine mounts (ACMs) notably contribute to ensuring superior effectiveness in vibration attenuation. This paper incorporates a PID controller into the active control engine mount system to attenuate the transmitted force to the body. Furthermore, integrated time absolute error (ITAE) of the transmitted force is introduced to serve as the control goal for searching better PID parameters. Then the particle swarm optimization (PSO) algorithm is adopted for the first time to optimize the PID parameters in the ACM system. Simulation results are presented for searching optimal PID parameters. In the end, experimental validation is conducted to verify the optimized PID controller. The study demonstrates that the improved PID controller reveals effective vibration isolation performance.