Transmission spin loss has significant influence on the vehicle fuel economy. Transmission output chain may contribute up to 10~15% of the total spin loss. However, the chain spin loss information is not well documented. An experimental study was carried out with several transmission output chains and simulated transmission environment in a testing box. The studies build the bases for the chain spin loss modeling and depicted the influences of the speed, the sprocket sizes, the oil levels, the viscosity, the temperatures and the baffle. The kriging method was employed for the parameter sensitivity study. A closed form of empirical model was developed. Good correlation was achieved.