Electrification has been considered one of the major solutions to meet stringent US fuel economy and CO2 targets of 2025. Numerous published researches are mainly focused on improving fuel economy for passenger cars, but less has been done for larger size light-duty vehicles, such as pickup truck, SUV and minivan, which contribute to a considerable amount of vehicle sales in the US market. Due to the vehicle size, it is expected that ideal electrification architecture is different than that of the passenger car. The purpose of this study is to identify the best electrification strategy for an existing class 2 pickup truck for fuel economy improvement, while taking into account cost effectiveness for large market penetration. Vehicle electrification configuration concepts are examined by computer simulations. A design of experiment (DOE) is conducted to specify electric powertrain components for each configuration concept. Simulation models are analyzed on three different standard cycles (i.e., Urban Dynamometer Driving Schedule, Highway Fuel Economy Test, and US06) and a Real World Drive cycle.