Fuel cell vehicles are entering the automotive market with significant potential to reduce harmful greenhouse emissions, facilitate energy security, and increase efficiency while providing expected driving range and fill times. One of the challenges for the successful commercialization of this technology is transitioning the on-board fuel system from gasoline as a liquid to hydrogen as a compressed gas. In order to reduce the energy density gap, hydrogen needs to be compressed to 700 bar, which still requires 7 times greater volume in comparison to gasoline. The improved efficiency of a fuel cell vehicle can assist in reducing the required volume increase to 4 times for an equivalent driving range. Based on need to store high pressurized hydrogen, it should be evident that a hydrogen tank requires a specialized structural pressure vessel, significantly different in function from a gasoline container. In the late 1990s, the industry first developed hydrogen tanks based on traditional type 3 and 4 compressed natural gas (CNG) tank constructions at 250 bar. As fuel cell vehicles developed along with the need for greater driving range, the OEMs progressed the hydrogen storage pressure to 350 bar and then to 700 bar, which is currently the industry norm. Even with the progression in pressure, the initial pressure vessels still continued to be manufactured using the materials and approach from the CNG tank technologies. Over the past 5 to 10 years, there have been several needed advancements with on-board 700 bar compressed hydrogen tank systems. These advancements include efforts funded by the Department of Energy such as the project by Pacific Northwest National Laboratory in novel tank designs and Oak Ridge National Lab in development of lower cost carbon fiber. In addition, other design considerations will be evaluated in a performance sensitivity analysis using finite element modeling. This paper will summarize these opportunities and consider the outlook for on-board 700 bar compressed hydrogen tank systems to achieve the commercialization goals for fuel cell vehicles.