48V battery packs, with rated power capabilities up to 16kW, are rapidly becoming a new standard in the automotive industry. Improving on their 12V counterparts (2-5kW), 48V Mild Hybrid Electric Vehicles (MHEV) allow for extended start-stop and regenerative braking functionalities, providing fuel economy benefits of up to 10-15% in standard passenger vehicles. New and relatively unexplored opportunities exist to further increase the fuel economy performance of 48V systems. Such capabilities include electric supercharging, electric boost, electric power steering, electric suspension and electric air conditioning (AC). Improvement in battery power (20kW or higher) would further enable hybridization to near-HEV levels as well as engine downsizing, thus paving the way to fuel economy improvements beyond the current 10-15% MHEV limit. Such novel capabilities require the development of 48V battery packs with a high power-to-energy ratio. In this talk, we will explore the various opportunities for fuel economy improvements in advanced 48V systems and link these capabilities with requirements at the cell level. Impacts of vehicle electrification topology and strategy and their impacts on optimized battery characteristics will be investigated. Special attention will be given to the LiFePO4 chemistry, whose excellent rate capabilities allow to approach the high power targets of next-generation 48V systems while minimizing capacity over-sizing. A combination of experimental measurements, vehicle-level fuel economy simulations and electrochemical analyses will be used in this study.