Industry trends towards lighter, more aerodynamically efficient road vehicles has the potential to degrade a vehicle’s response to crosswinds. In this paper, a methodology is outlined that indirectly couples a computational fluid dynamics (CFD) simulation of the vehicle’s aerodynamic characteristics with a multi-body dynamics simulation (MBD) to determine yaw, roll and lateral response characteristics during a ‘severe’ crosswind event. This indirect coupling approach mimics physical test conditions outlined in open loop test method ISO 12021:2010 that forms part of the vehicle sign-off criterion at Ford Motor Company. The methodology uses an overset mesh CFD method to drive the vehicle through a prescribed crosswind event, providing unfiltered predictions of vehicle force and moment responses that are used as applied forces in the MBD model. The method does not account for changes in vehicle attitude due to applied aerodynamic forces and moments. Traditionally, a vehicle’s crosswind response is simulated using curve-fits from quasi-steady-state aerodynamic tests across the yaw polar as input conditions for the MBD simulation. Comparisons are made between the indirect-coupled and quasi-steady methodologies and physical test data obtained for two ‘all new’ vehicles developed at Ford Motor Company of Australia, the Ford Escort mid-sized Sedan and the Ford Everest large SUV. Excellent agreement is demonstrated between indirect-coupled analytical and physical data for the vehicle response during the crosswind event. Whilst the quasi-steady approach tends to under-predict crosswind responses for both vehicles, the indirect-coupling approach yields predictions for yaw rate, roll rate and lateral accelerations that fall within the variability of experimental data. It is inferred that improvements in the predictive capability using the indirect-coupling approach is related to the ability of the overset mesh approach to capture the transient aerodynamic response of the vehicle, as it enters and exits the crosswind event.