Hypoid gears transmission error (TE) is a metric that is usually used to evaluate their NVH performance in component level. The test is usually done at nominal position as well as out of positions where the pinion and gear are moved along their own axis and also along offset direction to evaluate sensitivity of the measured TE to positional errors. Such practice is crucial in practical applications where the gear sets are inevitably exposed to off position conditions due to a) housing machining and building errors, b) deflections of housing, bearings, etc under load and c) thermal expansions or contractions of housing due to ambient temperature variations. From initial design to development stage, efforts should be made to design the gear sets to be robust enough to all combinations of misalignments emanated from all three mentioned categories. This study is one such effort a) to evaluate main parameters affecting TE response of a hypoid gear set at various misalignments conditions including temperature variations, b) focusing on topography (ease-off) effect on TE response under load-misalignments, approximating ease-off through a bi-cubical polynomial studying the effect of different topography errors including pressure, spiral etc. errors on TE response.