This paper explores the potentiality of reducing noise and vibration of a vehicle transmission thanks to powertrain control integration with active braking system. The torsional backlashes between transmission rotating components (gears, synchronizers, splines, CV joints), in the presence of external disturbances, coming from the driver, e.g. during tip-in / tip-out maneuvers, or from the road, e.g. crossing a speed bump or driving on a rough road, may lead to NVH issues known as clonk. In this study, first of all the positive effect of a brake torque application at the driving wheels during such maneuvers on transmission NVH performance is shown. After that, a powertrain/brake integrated control strategy is proposed. The braking system is activated in advance with respect to the perturbation and it is deactivated immediately after to minimize the energy loss. Meanwhile the powertrain control compensates for the added motion resistance and reestablishes the vehicle longitudinal performance according to driver’s commands. The torsional preload created in the driveline is effective to prevent/reduce vibrations and the associated noise. It is worth underlining that the proposed methodology can be directly apply to existing ABS/ESC units, composed of digital solenoid valves, and does not require additional hardware components. The effectiveness of this method has been experimentally validated by means of a Hardware In the Loop (HIL) test bench which includes a Dual Clutch (DCT) transmission and a hydraulic brake system with a customized ABS/ESC unit.