NVH (Noise Vibration & Harshness) is one of the main focus areas during the development of products such as passenger cars or trucks. Physical test methods have traditionally been used to assess NVH, but the necessity for reducing cost and creating a robust solution early on in the design process has driven the increased usage of simulation tools. Development of well-defined methods and tools for NVH analysis allows today's OEMs to have a Virtual Engineering based Development Cycle from Concept to Test. However, not all NVH problems have been focused on, including the issue of Squeak and Rattle (S&R). In a vehicle, S&R is a recurring problem for interior plastic parts such as an Instrument Panel or Door Trim. Since 2012, Altair has been developing S&R Director (SnRD), which is a solution that identifies and combats S&R issues by embedding E-Line methodology  . This methodology is based on Industry Best Practices, as described in the paper SAE 2012-01-1553. This Simulation based solution is about predicting the risk for S&R for trim parts, identifying the root causes, and proposing solutions to the projects via robustness analysis and optimization. This type of simulation integrates Design & Manufacturing Data (GD&T) as well as advanced material testing data. Keywords: Squeak & Rattle, NVH, Vehicle Interior Development, Simulation & Optimization Driven Design, E-Line method in SnRD.