This work aims to provide theoretical basis for improving engine shake performance based on full vehicle model by optimizing the design parameters of hydraulic engine mounts (HEMs). The definition of the engine shake problem is presented through comparing the quarter vehicle models with the rigid-connected and flexible-connected powertrain which is supported by a rubber mount. Then the model is extended by replacing the rubber mount as a HEM with regard to the inertia and resistance of the fluid within the inertia track. Based on these, a full vehicle model with 14 degree of freedoms (DOFs) is proposed to calculate the engine shake, which consists of 6 of the powertrain, 1 of the fluid within the inertia track of the HEM, 3 of the car body and 4 of the unsprung mass. Parameter study is performed to determine the most effective parameters of the HEM influencing engine shake and then the HEM is optimized through the genetic algorithm (GA). It can be found a remarkable improvement in mitigating vibration is achieved.