Due to the particularity of the goods, the collision of dangerous goods transport vehicles such as tanker truck may lead to explosion, leakage and environmental pollution, causing great harm to society and the environment .This paper focuses on the effects of different loads (no load, half load, full load) on key parameters of autonomous emergency braking system for tanker truck. The autonomous emergency braking algorithm model is established according to the kinematic equation of the vehicle. And the autonomousemergency braking algorithm is simulated by PreScan and Simulink under different scenarios. After that, the simulation-optimized algorithm has been tested on a real vehicle. The influence of the tank load on the TTC triggering threshold of emergency braking and the braking distance is the focus of the simulation and the real vehicle test. For the different load conditions, the automatic emergency braking system simulation data and real vehicle test data have been compared, the result shows that: At the same speed, as the tanker load increases, the TTC triggering threshold of emergency braking increases; At the same speed, as the tanker load increases, the braking distance increases. At last, based on these results, the autonomous emergency braking algorithm for tanker truck is optimized and presented in this paper.