The dielectric barrier discharge (DBD) has seen significantly increased levels of interest for its applications to various aerodynamic problems. The DBD produces stable atmospheric-pressure non-thermal plasma with highly energetic electrons and a variety of ions and neutral species. The resulting plasma often degrades the dielectric barrier between the electrodes of the device, ultimately leading to actuator failure. Several researchers have studied a variety of parameters related to degradation and time-dependent dielectric breakdown of various polymers such as PMMA or PVC that are often used in actuator construction. Many of these studies compare the degradation of these materials to that of borosilicate glass in which it is claimed that there is no observable degradation to the glass. Recent research at West Virginia University has shown that certain actuator operating conditions can lead to degradation of a glass barrier and can ultimately result in failure. This study has aimed at estimating the dominant electrical operating factors in the degradation process and has investigated the effects of varying voltage, frequency, and duty cycle (pulsed operation) on a borosilicate glass barrier. Experimental results of mean time to failure are also compared to various theoretical model predictions.