The paper is devoted to simulation of A320 wing assembly on the base of numerical experiments carried out with the help of ASRP software . The main goal is to find fasteners’ configuration with minimal number of fastening elements that provides closing of admissible initial gaps. However, for considered junction type initial gap field is not known a priori though it should be provided as input data for computations. In order to resolve this problem the methodology of random initial gap generation based on available results of gap measurements is developed along with algorithms for optimization of fasteners' configuration on generated initial gaps. Presented paper illustrates how this methodology allows optimizing assembly process for A320 wing. 1. Lupuleac, S., Petukhova, M., Shinder, J., Smirnov, A. et al., "Software Complex for Simulation of Riveting Process: Concept and Applications," SAE Technical Paper 2016-01-2090, 2016, doi:10.4271/2016-01-2090.