Engine Knock is a stochastic phenomenon that occurs during the regular combustion of spark ignition (SI) engines and limits its efficiency. Knock is triggered by an autoignition of local “hot spots” in the unburned zone, ahead of the flame front. Regarding chemical kinetics, the temperature and pressure history as well as the knock resistance of the fuel are the main driver for the autoignition process. In this paper, a new knock modeling approach for natural gas blends is presented. It is based on a kinetic fit for the ignition delay times that has been derived from chemical kinetics simulations. The knock model is coupled with an enhanced burn rate model that was modified for Methane-based fuels. The two newly developed models are incorporated in a predictive 0D/1D simulation tool that provides a cost-effective method for the development of natural gas powered SI engines.